Abstract
Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Interest in early diagnosis and effective therapy of this disease is steadily growing. The progression of malignant tumors, as well as the effectiveness of treatment and prognosis of disease development, are closely related to changes in the immune system. Cytokines are protein signaling molecules that play a key role in the interaction between cells of the immune system and other body systems. Recent studies have revealed the influence of cytokines on the development of malignant tumors of the stomach. Cytokines are involved in the process of carcinogenesis, exhibiting both pro-oncogenic and anti-oncogenic properties. Helicobacter pylori infection causes chronic inflammation in the stomach wall, which is the first step in the path of gastric carcinogenesis. The influence of cytokines on the development of GC in H. pylori infection has been noted. One of the most important aspects of the clinical characteristics of cytokines in GC is the prognosis of treatment effectiveness. In addition, studies of the role of cytokines in gastric cancer are important for diagnostics and open up new approaches to therapy.