Abstract
Benign salivary gland tumors, though non-malignant, can significantly affect the function of glandular tissue, leading to changes in saliva composition. This study investigates the biochemical alterations in saliva among patients with benign salivary gland tumors, aiming to explore saliva as a non-invasive diagnostic tool for early diagnosis and disease monitoring. To examine the biochemical composition of saliva in patients with benign salivary gland tumors and compare it to that of healthy individuals, focusing on changes in protein fractions, enzyme activities, and electrolyte levels. Forty-two patients diagnosed with benign salivary gland tumors (18 men, 24 women, aged 25–65) participated in the study. A control group of 20 healthy individuals was also included. Saliva was collected in the morning, and biochemical analysis was performed to measure total protein, protein fractions, enzyme activity (amylase, lactate dehydrogenase), and electrolyte levels (Na+, K+, Ca2+, Cl−). Data were analyzed using SPSS 25.0. Significant differences in saliva composition were observed in patients compared to the control group. Protein levels were significantly higher (p < 0.05), with increased globulins and decreased albumin-globulin ratio. Enzyme activity, especially amylase and lactate dehydrogenase, was elevated, and electrolyte imbalances were noted.